It is a new method applied by injection of natural products containing collagen to different regions in painful diseases of musculoskeletal system. The purpose of local application of these bio products is to renew, strengthen and protect the application area. Cartilage, connective tissue, joint capsule, such as dense collagen-containing structures affected by external collagen injection of these structures provide mechanical strengthening. Ampoules containing collagen are injected subcutaneously into appropriate sites. As a result of the collagen vaccine, these structures are strengthened and renewed in this region, pain is eliminated.